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Swine flu H1N1/2009 strikes McPherson household

Posted on Monday, September 14, 2009 at 10:06AM by Registered CommenterScott McPherson in | Comments13 Comments

Well, it was an interesting weekend.  It all started Friday afternoon, as the day was winding down.  I got a call from my daughter, Mailin, who teaches fifth grade at a local private school.  She was suddenly feeling quite ill after an otherwise uneventful day, and had gone to the school clinic.  Her temperature: a hair under 102 degrees F.

What should she do, she asked?  I told her to immediately go home and go to bed.  I then called my wife and told her to get a box of Tamiflu from our strategic reserve and place it in her room and to start her on Tamiflu immediately.

When our daughter got home, she actually misread the directions and took two Tamiflu capsules (this may factor in later in the story), and went straight to bed.  My wife prepared chicken soup and gave a heaping portion to her, along with two Advils.  She complained of headache; a very sore throat; body aches; she had suddenly acquired a nasty-sounding cough; and she was in extreme fatigue.

I, of course, sprung into immediate action, and went straight to the football stadium to call the Lincoln High football game (a 28-3 win over Daytona Beach Spruce Creek).  On the way home, I stopped at Wal-Mart and bought out their remaining supply of N-95 respirators along with an extra box of disposable gloves.  When I returned home, my wife and I "masked up," donned gloves and entered her bedroom, now referred to as her "bubble."  My wife took her temperature while I pulled "solid surface detail," cleansing every possible solid surface she had touched in her bathroom and bedroom with Clorox wipes.  Her fever had reduced to just over 101 degrees F.

I also suggested to my wife, who is a recent chemotherapy patient, that she should start on Relenza immediately as a preventative.

The following morning, her fever had returned, registering nearly 102 degrees F again.  We immediately "masked and gloved up" and repeated the previous evening's work.  Since she had taken twice the normal dose of Tamiflu the day before, she had not had any Tamiflu since around 4PM Friday.  So my wife gave her the first Tamiflu of the new day, while I cleaned and cleaned and cleaned some more.

Now I am reminded of what Jesus Christ said about being a prophet in one's own country.  To paraphrase, being a "flu expert" in one's own household means getting a second opinion.  So my wife called our family doctor and left a message.  Soon enough, a call came from one of the nurses on duty.  My wife Marta relayed all the symptoms.  Additionally, she conveyed the results of a phone call received that morning from another teacher at the school.  A child in Mailin's class had tested positive for swine flu.  Marta also disclosed that we had placed our daughter on Tamiflu.

Yes, the nurse said, that fits the bill for swine flu.  Keep Mailin on the antiviral.  Also, she instructed us to both go on Tamiflu as a preventative.  Marta hung up the phone and looked at me.  I, of course, being the loving husband I am, took every opportunity to remind her that the doctors completely agreed with my diagnosis and treatment.  She, in turn, refused to go on Relenza but did start on Tamiflu, one capsule a day -- the same dosage I had recommended.

Now Relenza is an interesting medication.  I knew it used an inhaler but had never worked the damn thing before.  I always thought it worked like an asthma inhaler.  Wrong!  Theory is one thing; practice is another.  Fortunately, Glaxo has a full-color, photo-filled set of instructions so complete that even a middle-aged dude who hates to read the manual can follow along.  Pull off the blue cover to the mouthpiece.  OK.  Now pull out the mouthpiece until it clicks.  Now pinch the little doobers and withdraw the full apparatus.  WTF!  Now open the cylinder that came with the inhaler and withdraw the disk with the four little bubbles on it, looking like the bottom of the UFO from The Invaders.  Place the disk into the slot, bubbles down.  Now close it all back up.

But wait, as the late Billy Mays would say, there's more!  Now lift up this lever and lift it until it is completely perpendicular to the inhaler.  KEEP EVERYTHING LEVEL or you'll spill the medicine!  Okay, okay!  Now return the lever to its original position and exhale as much as you can!  Now INHALE DEEPLY while keeping the inhaler level, but DON'T COVER THOSE LITTLE HOLES ON EITHER SIDE OF THE MOUTHPIECE!  Okay, okay!  Now hold your breath and let the medicine get deep into your lungs!

I held my breath and kept the air in my lungs as long as I could, taking care not to cough and expunge all that medicine.  All this reminded me of some questionable activity I engaged in way back in my youth, when holding stuff in the lungs was de rigeur,if you catch my drift.  Then I had to exhale and pulled out the mouthpiece, which turned the disk one quarter turn, prepping the next dose of Relenza.  I lifted the lever, puncturing the next blister, and re-inhaled.

That afternoon, our daughter ate some more, and in the evening, her fever had stabilized.  She took her evening Tamiflu and stayed in bed.

Sunday, we repeated the exercise.  She began feeling somewhat better and was very thirsty.  Today, she is doing much, much better.   She asked, When can I come out of my bubble! Once we know she is fever-free for 24 hours without the assistance of fever-reducing medications, she should be able to return to her teaching duties.

I have been doing this Relenza regimen for three days now, two puffs a day.  My wife is still on Tamiflu and I credit her with making a sound decision.  The  inhaler for Relenza is a bit of a bother! 

Here are some takeaways from my experience:

First, having a private stockpile of Tamiflu is very beneficial.  Not everyone can have as sympathetic a doctor as I, but having the stuff on hand meant she did not have to wait an extra minute for antivirals to be purchased.  That, in my opinion, was a huge advantage.  Otherwise, she would have had to wait until a prescription was called in.  And what if the local pharmacy had been sold out of Tamiflu?  We would have been forced to do what Australian mothers did last year; namely, drive across their cities in a vain search for antivirals.

And with my daughter's cough, there was no bloody way she was going to be able to take Relenza deep enough into her lungs.  No way.

Second, being well-versed in the symptoms of influenza was absolutely important.  Knowing when to pull the trigger was based on sound diagnosis and making quick decisions.

Third, Tamiflu is an amazing substance!  We know a family whose child's temperature reached 105 degrees F. until it began to subside.  Contrast this with the shortened fever cycle experienced by our daughter.  I am all about Tamiflu!  I agree with the late Graeme Laver that it should be an over-the-counter medicine today.  My daughter (she is 26) has had zero side effects.  Neither has my wife. And neither have I with Relenza, save for some issues with lung capacity. ;-)

Fourth, you can't find enough solid surfaces to clean.  Light switches, door handles, sink knobs, toilet flushers, toilet seats, and on and on and on.  But you've got to hit them all, to make sure you nailed the virus.

Fifth, we are still monitoring our daughter's cough.  If it gets worse, or doesn't get better very soon, off to the doctor she will go.  As we all know, pneumonia -- both bacterial and viral -- is a persistent side effect of this flu (or any flu, really).  So we are very sensitive to that cough and what it could still turn into.  That is also, quite frankly, why she did not return to work today. That, and the desire to ensure completely fever-free behavior for 24 straight hours.

Sixth, it is absolutely amazing how quickly this virus hits.  The day before, she was fine and full of vigor.  This reminded me that she had been shedding virus for at least a day or two prior to the onset of symptoms, and meant my wife and I had both come into contact with the virus.  We won't know if our ages or the antivirals (or both) might have warded off this virus, but ordinarily both of us should have been stricken with the flu by now.  The fact that three days have passed (even more when you factor in the incubation period) and we are not feeling sick is testament to quick preventative use of antivirals.

Seventh, I cannot help but wonder if "doubling up" accidentally on the initial dosage of Tamiflu was beneficial.  We having double the amount of antivirals a huge kick, like doubling the first dose of antibiotics? 

All in all, it was a unique chance to put theory to practice and to apparently come out of it none the worse for wear.

So how was your weekend?

Reader Comments (13)

N-95s? Scott, unless you and the missus have been fit-tested, N-95's are really no better than your average, way less expensive surgical masks. Go get your money back.

September 14, 2009 | Unregistered CommenterAlgerine

A wonderful description of an optimum level of preparedness. Thank you, Mr McPherson for your help. Good Luck!

September 14, 2009 | Unregistered CommenterGiuseppe Michieli

What a story!
I hope you and your wife have built up some immunity even if you were asymptomatic. Your daughter is very fortunate to have you take care of her like you did.

Sounds like Relenza is a pain. We thought about getting some Tamiflu without prescription, but it was very expensive and then times that by 5!
Eeek!

I'm afraid the medical community is not prepared for the thousands upon thousands that will show up at their door DEMANDING Tamiflu or Relenza.

September 14, 2009 | Unregistered CommenterCindy in Nerstrand, MN

The whole swine flu story leaves a question begging to be answered: If IV peramivir is effective in the ICU and has been shown to be safe in Phase I and II trials in the US, and Phase I, II and III trials in Japan, why has the FDA dragged its heels issuing an Emergency Use Authorization, and why have children suffocated to death in the ICU as a result? What Hurricane Katrina was to FEMA, this delayed EUA is to the FDA. It's a huge story; please break it.

September 14, 2009 | Unregistered CommenterMichael Murphy

Scott: I am new to your blog (directed via Avian Flu Diary), so please forgive me if this question regards an issue you have covered before. I was wondering why you chose to go on prophylactic Relenza, rather than prophylactic Tamiflu. The reason I'm asking is this: Although my friends think I'm cuckoo (and maybe I am), my 4-year-old daughter (who has some health issues) and I are self-quarantining at home until the pandemic vaccine is available. My husband wants to take a plane trip for his 20th high school reunion in early October (just a few weeks before the vaccine will be available), but I didn't want to let him go. Now, however, we're thinking of having him go on prophylactic antivirals as a way to make the trip more safe (for him, and for us upon his return). I have a private stockpile of both Tamiflu and Relenza. At first I had thought he could take the Tamiflu prophylactically (since we have more of it, and I wanted to save the Relenza for if we need it later), But after reading about Tamiflu-resistant pandemic flu possibly spreading silently, I'm wondering if Relenza makes more sense for him to take prophylactically on his trip (and also as a treatment if we get the flu?).

By the way, from my reading of Dr. Grattan Woodson's Bird Flu Manual, I surmise that your hunch about doubling up on Tamiflu is correct. In his book, Dr. Woodson talks about research that showed H5N1 patients had a better survival rate when they had higher levels of Tamiflu in their blood (either by taking a double dose of Tamiflu or by taking Tamiflu together with Probenicid, a drug which extends the time Tamiflu stays in the bloodstream).

September 14, 2009 | Unregistered CommenterChristina

Hello everyone! Thanks for the comments and concerns.
Let me address two specific comments. First, I dediced to go on Relenza because of the tamiflu-resistance issue and because my wife was on Tamiflu as a preventative, so I figured I would try the inhaler and save the Tamiflu for later. I would still recommend Relenza, even with its "work."

Second, I would not self-quarantine, because there are so many opportunities for that quarantine to be broken, Mail and FedEx/UPS are the easiest to mention; paper needs to be auarantined as well. recall it was the postman who killed the Inuits in 1918.

That having been said: At this point, I would probably defer to Tamiflu as the antiviral preventative for travel. It is easier to carry and there is less risk of medicine spillage. I have written extensively on Probenecid (just search this blogsite) and agree that is a fine way to go!
Scott

September 15, 2009 | Registered CommenterScott McPherson

Re: Paramavir. I have written extensively on peramivir as well (just search this blogsite), and I have covered its highs and lows.

I do not disagree that in the ICU and in the most serious cases, it should be tried. But I am not sure it is ready for prime time. Not while we still have zanamivir and oseltamivir. However, I would push hard for peramivir in ICUs for the third wave, when we might see some changes in the virus.

September 15, 2009 | Registered CommenterScott McPherson

Hello Scott:
I am ill this week with the so-called "fever-less swine flu" It started Sunday with aching and flu like feelings. The absence of a fever confused me. But my husband, with 30 years as an ER doctor, said many cases do not have fever. The ER's are current overwhelmed with swine flu in Texas. I am reading that the absence of fever is actually a mutation of H1N1 and something that has global implications. Do you have an opinion on the PB2 factor involved in swine flu without a fever as a component?

Regards,
Allison in San Antonio

September 29, 2009 | Unregistered CommenterAllison

Question. My daughter and I both have asthma and she tested positive last week for H1N1. Her ped and my GP put us both on Tamiflu. My daughter was markedly better within 2 days, her fever lasting only 30 hours. The illness was very mild compared to what I was expecting. I never became ill.

I've had several people tell me that now that we've taken Tamiflu, we cannot take it again if were to be stricken with the flu again? I've looked quite a bit online and can't find any information on this. I would hope my daughter would immunity from acquiring the virus, but since I took it as a preventative, does this mean I'm SOL if I come down with the real thing? If that's the case, I don't think I would have taken the Tamiflu until I showed symptoms. I don't think I can take Relenza as it's not advised for asthmatics.

October 5, 2009 | Unregistered CommenterMary

Mary,
I have seen nothing in the literature to indicate you could not take Tamiflu again. I think this person is confusing this with Tamiflu resistance, which the flu, not your body, would have to acquire.

The surest way for you to be covered is to get the flu shot (not the nasal vaccine) as soon as it is out. You would fall into the 5 target groups as an asthmatic.
Scott

October 15, 2009 | Registered CommenterScott McPherson

Allison,
Lack of fever is estimated in some 30% of H1N1v cases. So it is not an uncommon occurrence. However, what happens within PB2 is literally anyone's guess. I am blogging on this topic later, maybe today (you don't know what you don't know).
Scott

October 15, 2009 | Registered CommenterScott McPherson

Scott

Thanks for the description of how things went.

Reality is so much more informative than theory!

By the way, I always used approx a double dose as a loading dose...

...Even though it is based on sound theory, I'm not sure if other veterinarians or medical practioners do do the same...but it is certainly sound scientifically.

That may very well have headed off your daughters temp.

October 21, 2009 | Unregistered CommenterTom DVM

Hello Scott,
Thank you very much for your flu story. I was searching the internet for topics on what happens if you accidentally take a double dose of Tamiflu and I found this blog. This morning I got really scarred that I've taken a double dose (I am still not sure because my head is not working well - I am sick with a flu plus 34 weeks pregnant). I was feeling so horrible 3 days ago that I couldn't get up and go to neither ER nor doctor. So I called my OB and described the symptoms I was having (fever 101-102, headache, horrible pain in shoulders and lower back, chills, terrible dry cough, sinus) and they said I should go on Tamiflu immediately, and also take Tylenol Cold around the clock, plus Robitussin. So I did. I am feeling a little better - it's the third day - the fever is gone, as well as the headache and most of the body aches, but this terrible dry cough is still there (I have not slept because of this for 3 nights - as soon as a go into vertical position I am having an attack of this awful cough that lasts forever). And today a had this memory loss whether I've taken my dose of Tamiflu or not. I remember thinking about it but could not recall if I actually took it. So I've decided to take it anyway.... Is it going to be harmful for me being 34 weeks pregnant? I already had to overcome my initial fears whether I should take Tamiflu at all. And now the fears are even worse. Please advise.

October 31, 2009 | Unregistered CommenterNadya

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