Entries in influenza and infectious diseases (390)

Congo mystery illness update

Posted on Wednesday, September 5, 2007 at 03:57PM by Registered CommenterScott McPherson in | CommentsPost a Comment

It appears that we know as much about the Congo fever as we did before I took a Labor Day break.

From the WHO:

31 August 2007

dem-rep-of-congo-map.gifAn outbreak of an unknown illness with a high mortality has been reported from the province of Kasai Occidental, in the Democratic Republic of the Congo. The exact number of cases and deaths is unknown at this time. The clinical features in the majority of cases include fever, headache, diarrhoea or colicky abdominal pain, and vomiting. Over 50% of cases have been in children under 10 years of age.

An investigation team from the Provincial and National Health Ministries, the Institut National de Recherches Biologiques (INRB) and WHO is in the field, and has taken clinical samples for laboratory testing. WHO is mobilizing support for the epidemiological investigation and logistics, including supplies, and water and sanitation and technical partners in the Global Outbreak Alert and Response Network (GOARN) have offered to provide support to the MoH if required.

At the present time, the etiological agent is unknown but the national health authorities have taken a precautionary approach and are implementing measures to improve hygiene, ensure the safety of the water supply, promote safe burial practices and strengthen infection control.

What is noticeably missing from this report is the word "hemorrhagic".  Clearly, world public health organizations are rushing reinforcements into the area.  But not too quickly, I reckon.  From the BBC, and note the victims include medical staff:

Mystery DR Congo fever kills 100

More than 100 people have died because of a fever epidemic in the centre of the Democratic Republic of the Congo, health officials say.

Many of the victims are people who have been in contact with the deceased, including medical staff, and who lack equipment to deal with the illness.

The latest victim was a nurse at a local hospital. She died on Thursday after taking care of infected patients.

Health officials say the medical staff had no masks and this put them at risk.

Speaking from Kananga, the capital of West Kasai region, Dr Jean-Constantin Kanow said the illness had first started three months ago, when chickens and pigs started dying - but now people were also affected.  (bold mine).

The epidemic was affecting four villages: Kampungu, Makonono, Kaluamba and Mombo.

Funeral rites

Traditionally, people in DR Congo wash dead bodies by hand.

The doctor said that such funeral rites seemed to favour the transmission of the disease.

He said many people who attended the recent funeral of a local chief had also died of fever and dehydration.

The World Health Organisation has sent a team to take blood samples for analysis at laboratories specialising in haemorrhagic fever.

DR Congo's last major Ebola outbreak killed more than 200 people in 1995 in Kikwit, about 400km (249 miles) west of the current outbreak.

But health officials say it is too early to determine if this new epidemic outbreak is indeed a haemorrhagic fever.

Heart of Darkness

Posted on Thursday, August 30, 2007 at 11:42AM by Registered CommenterScott McPherson in | CommentsPost a Comment | References1 Reference

Fever grips Congo, over 100 persons dead

From the Times of India:


CGebola9174200.jpg30 Aug 2007, 0637 hrs IST,AP

KINSHASA: More than 100 people have died in a remote part of Congo, including all those who attended the funerals of two village chiefs, in what health officials fear is an outbreak of hemorrhagic fever.

People began dying of the suspected fever after the high-profile funerals in Mweka, a region of southeastern Congo where relatives usually wash the bodies of the deceased by hand, said Jean Constatin Kanow, the chief medical inspector for the province.

In the past, Congo has seen large outbreaks of Marburg and Ebola, both hemorrhagic fevers caused by viruses that, in severe cases, attack the central nervous system and cause bleeding from the eyes, ears and other parts of the body.

``Everyone that attended those funerals is now dead,'' said Kanow. ``We began by suspecting typhoid fever, but now we believe its hemorrhagic fever.''

In all, four villages are affected and 217 people have come down with the illness, including 103 who died. Of the dead, 100 were adults and three were children, said Kanow.

Two medical teams from the province's administrative seat have been sent to Mweka, an area with a population of 140,000. A third team, from the National Institute of Biomedical Research, was expected to arrive Wednesday from Kinshasa, the capital, 690 kilometers (430 miles) northwest of Mweka.

The researchers were planning to take blood samples to be analysed at laboratories specializing in hemorrhagic fever.

Congo's last major Ebola outbreak struck in Kikwit in 1995, killing 245 people. Kikwit is about 300 kilometers (185 miles) from the site of the current purported outbreak.

 

ebola%20ivory%20coast.jpgEbola is such an efficient killer, it is its own agent of destruction.  It kills so quickly and so violently that people (normally) do not have the ability to leave their villages before the disease strikes.  This, as opposed to influenza, whose goal is more "peaceful coexistence," as it cannot really live outside the host.

But if for some unknown reason Ebola, or Marburg, ever mutated to the point where it could incubate for longer periods of time before it became lethal -- that is too frightening, even for me.

This is the biggest outbreak of hemorrhagic fever I can remember for some time.  Let's watch this carefully.

Further (grim) evidence Non-Pharmaceutical Interventions work

Posted on Thursday, August 30, 2007 at 10:54AM by Registered CommenterScott McPherson in | CommentsPost a Comment

070829-venice-plague_big.jpgNational Geographic is reporting that on the island of Lazzaretto Vecchio, in the Venetian lagoon, a mass grave of bubonic plague victims has been unearthed.  From the National Geographic news release:

The island is believed to be the world's first lazaret—a quarantine colony intended to help prevent the spread of infectious diseases.

The lazaret was opened during the plague outbreaks that decimated Venice, as well as much of Europe, throughout the 15th and 16th centuries A.D. Its presence may have helped Venice recover more quickly during the devastating outbreaks...

The concept of a lazaret began in 1485, when a devastating plague outbreak hit Venice and killed even the doge, or the head of state, at the time, Giovanni Mocenigo. Venice's government built a public hospital on Lazzaretto Vecchio to isolate the infectious and curb the disease's spread. At the time the island was named Santa Maria di Nazareth, but people also called it Nazarethum or Lazaretum. The second name prevailed and eventually gave rise to the modern word "lazaret."

But conditions in Lazzaretto Vecchio during plague outbreaks were far from modern hospital's standards. "It looked like hell ... The sick lay three or four in a bed," wrote the 16th-century Venetian chronicler Rocco Benedetti. "Workers collected the dead and threw them in the graves all day without a break. Often the dying ones and the ones too sick to move or talk were taken for dead and thrown on the piled corpses."

The lucky ones who survived and recovered spent their convalescence on the near island of Lazzaretto Nuovo.

Thanks to this policy, Venetians were able to curb the damage as the plague struck Europe again and again during the Renaissance... The remains belong to men, women, and children alike. Some show Asian or African features, evidence of the cultural diversity that stemmed from the Republic of Venice's role as one of the most important commercial ports in Europe.

It is fascinating to read that historians speculate that this policy may have saved Venice.  The article also goes on to say that rich and poor alike were treated equally during the plague: 

"Nobles or lower class didn't make any difference," Gambaro said. "All the sick were forced to stay on Lazzaretto Vecchio, and if they died, they were buried together."

Although today's standards will call for a much higher standard of health care, the discovery -- laden with artifacts, documents and bones, is another confirmation -- calling to us from centuries past -- that NPIs such as isolation and quarantine work.

 

Letter to Jakarta Post from Bali resident (from Effect Measure)

capt_bali10908170636_indonesia_bird_flu__bali109.jpgA blog or two ago, I mentioned that the people of Indonesia would tire of incessant government denials, lies and subterfuge in the battle against H5N1 avian influenza.

A letter writer in the Jakarta Post gives a chronicle of the frustrations Bali islanders must be feeling right now regarding their island paradise's descent into Bird Flu Hell. 

First, veteran blogger FLA_MEDIC has reported that another Bali child is sick and in hospital with symptoms of bird flu.  His post can be found here. http://afludiary.blogspot.com/2007/08/new-suspect-case-in-bali.html

Now the excellent public health blogsite and forum Effect Measure, recently affiliated with ScienceBlogs.com, has revealed an unbelievable letter from a resident of Bali.  The blog and letter can be found here. http://scienceblogs.com/effectmeasure/2007/08/bird_flu_in_indonesia_these_ne.php

In a nutshell, Giuseppe Verdacchi, a resident of the capital city (!) of Denpasar, reports to the Post about his frustrating inability to get any government official on Bali to help him dispose of a dead wild bird he found on his property.  particularly enlightening is the admonishment of his village leader.  Quoting from the blog/letter:

I tried then to contact the head of my village (in the Kerobokan area) and his reaction was: "Just bury the bird, there is no problem." How would he know?

As the "Reveres" of Effect Measure so eloquently and accurately point out:

Mind you, this is the country with more cases and more bird flu deaths than any other country in the world. The island of Bali, a major tourist area, has had two recent deaths from bird flu. The Indonesian authorities have been vocal and self-righteous about other countries profiting from influenza virus sequence information and viral isolates obtained from cases within their borders and for this reason do not consistently share this information with the world scientific community. Yet at the same time, through negligence, corruption and incompetence Indonesian authorities allow a continuous breeding ground for a virus that threatens everyone on the globe.

With the hospitalization of today's patient, the list of suspected H5N1 cases in Bali grows to 12.  Five have been sent home with negative test results; four are dead, and we are awaiting results of tests on the last death; and three remain hospitalized, awaiting test results.  And with the exception of the index case and her mother, the remaining cases are all within 20 km of the capital city.

 

Bali will filter (censor) H5N1 outbreak news

murray_hamilton6.jpgYet again, a mighty tip of the cap to the intrepid blogger at birdflunewsflash.com, a site living up to its domain name.  The site reports that the government of Bali has decided to call in the spin doctors and will filter all news regarding human and bird H5N1 infections.

The link to the blog is here, http://birdflunewsflash.wordpress.com/2007/08/29/bali-to-censor-news-about-the-current-bird-flu-outbreak/

and the link to the Jakarta Post story is here. Could we put these intrepid Jakarta Post staff writers up for a global Pulitzer?  http://www.thejakartapost.com/detailbali.asp?fileid=20070829.D08&irec=1

Now back to the analysis.

It seems Bali is taking the Mayor Larry Vaughn approach to their new bird flu situation.  That, of course, is to ignore the problem and try to spin its way out of it.  Let me pull some quotable quotes from the story.

The administration's spokesperson, Anak Agung Bagus Netra, on Tuesday said Governor Dewa Beratha had ordered all information regarding bird flu be delivered only by the public relations department.

"We are talking about a new outbreak here. We can't have (ill-informed) people speaking about it on behalf of the administration. This is about Bali's image. These days any information can fly overseas in a second," he told The Jakarta Post.

OK, so the spin doctors have now used the word outbreak.  I don't know if we would consider the Bali cases/deaths an outbreak just yet, but the Bali government seems perfectly content to accelerate the danger themselves. You've got ill-informed people speaking for the government now. Reading on:

Farmers are questioning new poultry regulations issued by the administration in an effort to eradicate H5N1 from the province. Bali deputy governor Alit Kesuma Kelakan last Sunday hinted at the idea of culling all fowl on the island, without elaborating on compensation for farmers.

Meanwhile, Udayana University virologist Ngurah Mahardika suggested that tourist destinations such as Kuta, Sanur and Nusa Dua be free from fowl, following the rapid spread of bird flu virus on the island.

"This is a better move than simply taking chicken off menus," Ngurah told the Post over the weekend.

The de-fowling of Bali will place local farmers directly at odds with tourist officials, hoteliers and restaurateurs.  Killing poultry without compensation is a prime factor in the re-emergence of H5N1 in flocks, according to multiple sources all over the planet.  Witness the laughable escapade in Egypt just last year, where farmers successfully and clandestinely moved a thousand chickens across town under the noses of Egyptian government cullers.  What Woody Allen or Mel Brooks could have done with that scene!  So Bali civic leaders had better pony up the money for the soon-to-be-dead chickens and ducks.

Ngurah said the human-fowl population density in Bali, especially in Denpasar, made the region prone to a bird flu outbreak. Lagging precautionary measures, Ngurah said, could help the virus spread and develop more quickly, thereby increasing the threat of a pandemic on the island.

2007%20august%20bali%2029F%20buried.jpgBy my count as of 4PM EDT on the 29th of August, a total of 11 people have been hospitalized with suspected H5N1 infections on Bali.  Four have died, and five have been released.  Two remain in hospital -- admitted in the past 48 hours.  Two of the four deaths are absolutely H5N1, and the index case -- the daughter of one of the dead -- died and was cremated before tests were able to be conducted.  It is strongly assumed she was infected with H5N1 and gave the virus to her 29 year-old mother, who in turn died and was buried (photo at left).  The fourth death is still to be resolved.  Whether or not the world gets the truth may be up to the Indonesian Health Minister, and we already know which side she is on. 

Additionally, thousands of poultry are being culled as we speak, as the Bali fathers desperately try to salvage their tourist season.  I certainly hope a secondary vector has not been established on the island yet.  Perhaps Bali should swab the throats of their housecats, too.

Dr. Henry Niman frequently utters an excellent quote:  "H5N1 does not read press releases."  Never has this been more appropriate than with this latest complication from Bali.